RuppertFoxBarnesInvertebrateZoology7thEdition VERIFIED
RuppertFoxBarnesInvertebrateZoology7thEdition
The impact of efflux pump activity on the antifungal susceptibility profile of caspofungin using an ex vivo model.
The impact of efflux pump activity on the antifungal susceptibility of caspofungin against 14 clinical isolates of Candida spp., including Candida parapsilosis, was determined using a human ex vivo model of infection. Caspofungin showed concentration-dependent fungistatic activity against all isolates when tested as either a single agent or in combination with a modulator of the multidrug-resistant (MDR) pump. Two isolates demonstrated a significant (2- to 5-fold) increase in their minimum inhibitory concentrations (MICs) for caspofungin when tested in the presence of the MDR pump inhibitor PSC-833 (50 nM). Although inhibition of the MDR pump by verapamil (20 microM) did not significantly impact the MIC of caspofungin in any isolates, the reversal of MDR pump activity for PSC-833 in isolates with increased MICs of caspofungin was sufficient to greatly reduce the antifungal activity of caspofungin against these isolates. We conclude that the concurrent use of efflux pump inhibitors with caspofungin may be useful in the management of cases of persistent or recurrent candidiasis due to MDR isolates.What’s Playing Where on Wednesday
The Gabby Douglas coverage continues
While we’re all riveted to the Olympics in Pyeongchang (and, frankly, a little distracted by the news about a U.S. skier facing a criminal indictment), this is a good time to take a breath and remember that the real competition in the Olympics is between TV and online media, and online media is winning that race.
So we want to make sure you keep tabs on this year’s big story. In the meantime, enjoy the great work NBC’s members have been doing on Gabby Douglas, up next.
The red carpet begins at 6:20 p.m. ET on sister site Today, of course, followed by the Opening Ceremonies, which will be simulcasted on NBC News and MSNBC beginning at 8 p.m. ET. (About two hours later, the Winter Games will officially start at the Games Center at 11:50 a.m. ET). No Olympics are complete without all the sweet cute pics of the athletes
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